Millennia of selective breeding have resulted in varieties that display a wide range of traits; e.g. suited for a particular environments/latitudes, producing different ratios and compositions of terpenoids and cannabinoids (CBD, THC, CBG, CBC, CBN...etc.), fibre quality, oil/seed yield, etc. Hemp grown for fiber is planted closely, resulting in tall, slender plants with long fibers.
μ-Opioid receptor agonists (opioids) (e.g., morphine, heroin, hydrocodone, oxycodone, opium, kratom) α2δ subunit-containing voltage-dependent calcium channels blockers (gabapentinoids) (e.g., gabapentin, pregabalin, phenibut) AMPA receptor antagonists (e.g., perampanel) CB1 receptor agonists (cannabinoids) (e.g., THC, cannabis) Dopamine receptor agonists (e.g., levodopa) Dopamine releasing agents (e.g., amphetamine, methamphetamine, MDMA, mephedrone) Dopamine reuptake inhibitors (e.g., cocaine, methylphenidate) GABAA receptor positive allosteric modulators (e.g., barbiturates, benzodiazepines, carbamates, ethanol (alcohol) (alcoholic drink), inhalants, nonbenzodiazepines, quinazolinones) GHB (sodium oxybate) and analogues Glucocorticoids (corticosteroids) (e.g., dexamethasone, prednisone) nACh receptor agonists (e.g., nicotine, tobacco, arecoline, areca nut) Nitric oxide prodrugs (e.g., alkyl nitrites (poppers)) NMDA receptor antagonists (e.g., DXM, ketamine, methoxetamine, nitrous oxide, phencyclidine, inhalants) Orexin receptor antagonists (e.g., suvorexant)
Cannabis plants produce a unique family of terpeno-phenolic compounds called cannabinoids, some of which produce the "high" which may be experienced from consuming marijuana. There are 483 identifiable chemical constituents known to exist in the cannabis plant, and at least 85 different cannabinoids have been isolated from the plant. The two cannabinoids usually produced in greatest abundance are cannabidiol (CBD) and/or Δ9-tetrahydrocannabinol (THC), but only THC is psychoactive. Since the early 1970s, Cannabis plants have been categorized by their chemical phenotype or "chemotype", based on the overall amount of THC produced, and on the ratio of THC to CBD. Although overall cannabinoid production is influenced by environmental factors, the THC/CBD ratio is genetically determined and remains fixed throughout the life of a plant. Non-drug plants produce relatively low levels of THC and high levels of CBD, while drug plants produce high levels of THC and low levels of CBD. When plants of these two chemotypes cross-pollinate, the plants in the first filial (F1) generation have an intermediate chemotype and produce intermedite amounts of CBD and THC. Female plants of this chemotype may produce enough THC to be utilized for drug production.
There has actually been a substantial amount of experiments done on cannabidiol that has proved its potential healing powers. Dr. Sean McAllister, a scientist from the Pacific Medical Center in San Francisco, made an astounding discovery about CBD. McAllister has been studying cannabinoid compounds for 10 years now in search of new therapeutic interventions for various cancers. He discovered that cannabidiol is a potent inhibitor of cancer cell proliferation, metastasis, and tumor growth.
Though there are some topical treatments, cannabis oil is typically administered orally to dogs. It also can be used in conjunction with traditional medications and treatments. Emerging research suggests there can be “synergistic benefits” between marijuana and traditional medications, Richter says. “There are few, if any, known significant drug interactions that you really need to be concerned about.”
Devinsky puts more weight behind the scientific advancements: In June, the FDA approved an epilepsy drug called Epidiolex, which contains a purified form of CBD oil. In controlled clinical trials, the drug was proven to reduce seizures in people with Dravet syndrome and Lennox-Gastaut syndrome — and it didn't produce as many of the unpleasant side-effects that come with other epilepsy medications.
Great quality, easy to find at nearby shop. I love the almost instant relief it brings. Was skeptical at first, never liked a tingly or cooling sensation from certain essential oils but this product is hands down the best and ill handle the icy sensation any day! Use it on my neck, back and knees, thank you for making a great accessible alternative for people!
Despite its centrality in human cultures across the globe, the European taxonomists who bequeathed Cannabis sativa its name didn’t quite get it right. When Carolus Linneaus came to naming the marijuana plant’s genus, he thought there was only one species, instead of the three we now know exist. Hence the confusion surrounding the fact that there are three distinct species of the genus Cannabis sativa, one of which is the sativa species.
Floyd’s of Leadville CBD Transdermal Cream uses the best anti-inflammatory strains that takes the edge off the pain and delivers an advantage over the competition. As you can expect from a Floyd’s of Leadville product there’s no preservatives or additives – just natural CBD hemp oil. Of course all our hemp is non-GMO so you get all of the goodness with none of the pesticides.
• In 2016, Dr. Stephanie McGrath, neurologist and assistant professor at Colorado State University’s College of Veterinary Medicine & Biomedical Sciences, completed a preliminary pharmacokinetic (what happens to a drug in the body) and safety study on CBD. Following this study, Dr. McGrath began two pilot studies involving owner-enrolled dogs with poorly controlled epilepsy and painful osteoarthritis. These have now ended and results on the epilepsy study are scheduled for publication in the Canadian Veterinary Journal later this year. One of its big-picture findings: 89 percent of dogs who received CBD had a reduction in the frequency of seizures. (McGrath and her team are now starting work on a larger epilepsy-focused project.)
On October 17, 2018, Canada legalized cannabis for recreational adult use making it the second country in the world to do so after Uruguay and the first G7 nation. The Canadian Licensed Producer system may become the Gold Standard in the world for safe and secure cannabis production, including provisions for a robust craft cannabis industry where many expect opportunities for experimenting with different strains. Laws around use vary from province to province including age limits, retail structure, and growing at home.
Scientists in Europe and North America concluded that hemp seed is an excellent source of nutrition. Numerous anecdotal incidences cited improvements in a wide range of acute and chronic conditions such as rapid healing of skin lesions and relief from flu, inflammation, and allergies. The benefits were attributed to the presence of rich source of the EFAs linoleic and alpha-linolenic acid, and their respective biologic metabolites, GLA and stearidonic acid.9
When we developed our Advanced Formula products in 2015 we decided instead to produce a much more concentrated product (like our Max) that was strong enough for a Giant Breed, but safe enough for a chihuahua. This requires much higher levels of not only hemp, but two dozen other compounds and terpenes unique to Canna-Pet®, and it allows us to produce two simple formulas to cover dogs of any size.
In Europe and Asia, hemp farming has been conducted for millennia. Although most countries ceased growing hemp after the second word war, some didn’t, including France, China, Russia, and Hungary, so that essential knowledge of how to grow and process hemp was maintained. When commercial hemp cultivation resumed in Canada in 1997, many farmers undertook to grow the crop without appreciating its suitability for their situation, or for the hazards of an undeveloped market. Hemp was often grown on farms with marginal incomes in the hopes that it was a savior from a downward financial spiral. The myth that hemp is a wonder crop that can be grown on any soil led some to cultivate on soils with a history of producing poor crops; of course, a poor crop was the result.
What is cannabis?Cannabis is a drug that comes from Indian hemp plants such as Cannabis sativa and Cannabis indica. The main active chemical in cannabis is THC (delta-9 tetrahydrocannabinol).Cannabis is a depressant drug. Depressant drugs do not necessarily make you feel depressed. Rather, they slow down the activity of the central nervous system and the messages going between the brain and the body. When large doses of cannabis are taken it may also produce hallucinogenic effects.For information on synthetic cannabinoids, see our "Legal high" facts page.Other namesCannabis is also known as grass, pot, hash, weed, reefer, dope, herb, mull, buddha, ganja, joint, stick, buckets, cones, skunk, hydro, yarndi, smoke and hooch.What does cannabis look like?Leaves from the cannabis plant are bright green and have a distinctive shape with five or seven leaflets. The flowering tops and upper leaves are covered in a sticky resin.Cannabis is used for the psychoactive (mind and mood-altering) effects of THC and other active ingredients. THC is the chemical in cannabis that makes you feel “high”.There are three main forms of psychoactive cannabis: marijuana, hashish and hash oil.Marijuana is the most common and least potent form of cannabis. Marijuana is the dried leaves and flowers of the plant.Hashish (“hash”) is dried cannabis resin, usually in the form of a small block. The concentration of THC in hashish is higher than in marijuana, producing stronger effects.Hash oil is a thick, oily liquid, golden brown to black in colour, which is extracted from cannabis. Hash oil is the strongest form of cannabis.How and why is it used?The different forms of cannabis are used in different ways:Marijuana is smoked in hand-rolled cigarettes (joints), or in a pipe (a bong).Hashish is usually added to tobacco and smoked, or baked and eaten in foods such as hash cookies.Hash oil is usually spread on the tip or paper of a cigarette and then smoked.Cannabis and hash can also be smoked in a vaporiser. Vaporisers heat cannabis to temperatures that release its active ingredients while minimising the toxins associated with burning.The THC in cannabis is absorbed into the bloodstream through the walls of the lungs (if smoked), or through the walls of the stomach and intestines (if eaten). The bloodstream carries the THC to the brain, producing the “high” effects. Drugs inhaled get into the bloodstream quicker than those eaten. This means that the effects of cannabis when smoked occur more rapidly than when eaten.Paper and textilesSome species of cannabis have few psychoactive effects. These plants are used to produce hemp fibre for use in paper, textiles and clothing.Medical usesCannabis has been used for medical purposes for many centuries. It has been reported that cannabis may be useful to help conditions such as:nausea and vomiting, particularly when associated with chemotherapywasting and severe weight loss, in people with HIV/AIDS, cancer, or anorexia nervosa, as it may be used as an appetite stimulantpain relief, for example in people with cancer and arthritisrelief from symptoms of some neurological disorders that involve muscle spasms, including multiple sclerosis and spinal cord injuryglaucomaepilepsyasthma.For more information, please click on the Australian Drug Foundation's DrugInfo Clearinghouse web site link below.
Last year, the Hemp Industries Association (HIA) estimated the total retail value of all hemp products sold in the U.S. at $620 million. Sadly, all of the raw hemp materials were imported from other countries. (More on that later.) Hemp is an attractive rotation crop for farmers. As it grows, hemp breathes in CO2, detoxifies the soil, and prevents soil erosion. What’s left after harvest breaks down into the soil, providing valuable nutrients.
^ Nadulski T, Pragst F, Weinberg G, Roser P, Schnelle M, Fronk EM, Stadelmann AM (December 2005). "Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract". Ther Drug Monit. 27 (6): 799–810. doi:10.1097/01.ftd.0000177223.19294.5c. PMID 16306858.
Since then, many different types of sex determination systems have been discovered, particularly in plants. Dioecy is relatively uncommon in the plant kingdom, and a very low percentage of dioecious plant species have been determined to use the XY system. In most cases where the XY system is found it is believed to have evolved recently and independently.
Hemp has been grown for millennia in Asia and the Middle East for its fibre. Commercial production of hemp in the West took off in the eighteenth century, but was grown in the sixteenth century in eastern England. Because of colonial and naval expansion of the era, economies needed large quantities of hemp for rope and oakum. In the early 1940s, world production of hemp fiber ranged from 250 000 to 350 000 metric tonnes, Russia was the biggest producer.
People have their reasons for vaping, and one of the most significant products that they use would be CBD oil. When you look at people, who vape, sometimes the first thing that comes into your mind is that they are looking for their everyday nicotine consumption. This is not the case for everyone who vapes. Many individuals nowadays vape CBD products because it helps them.
Without arguing the merits of the above contentions, we point out that the legitimate use of hemp for non-intoxicant purposes has been inhibited by the continuing ferocious war against drug abuse. In this atmosphere, objective analysis has often been lacking. Unfortunately both proponents and opponents have tended to engage in exaggeration. Increasingly, however, the world is testing the potential of hemp in the field and marketplace, which surely must be the ultimate arbiters. De Guzman (2001), noting the pessimistic USDA report, observed that “Nevertheless, others point to the potential of [the] market. Hemp products have a growing niche market of their own, and the market will remain healthy and be well supported with many competing brands.”
A neuron’s sensitivity to a specific neurotransmitter depends on whether or not it contains a receptor that “fits” that transmitter, like an electrical socket fits a plug. If a neuron contains receptors that match a particular neurotransmitter, then it can respond directly to that transmitter. Otherwise, it generally can’t. All neurons contain multiple neurotransmitter receptors, allowing them to respond to some neurotransmitters but not others.
The AKC Canine Health Foundation (CHF) is currently sponsoring a study, through the Colorado State University’s College of Veterinary Medicine and Biomedical Sciences, that will evaluate the use of CBD in treatment-resistant epileptic dogs. The CHF hopes that this will be the first study to gain scientific data on the use of CBD in dogs with this condition.